Introduction: Appendicectomy is one of the commonly performed surgeries in the emergency setup in our medical college (THANJAVUR MEDICAL COLLEGE). Aim of the Study: The study was conducted to know the effect of antibiotics in reducing surgical site infection and abscess formation after open appendicectomy.(1) Materials and Methods: A randomised controlled study was done in our medical college (THANJAVUR MEDICAL COLLEGE) between April 2019 and April 2020 in two groups. Group A received a single dose of postoperative antibiotic and group B received antibiotics for 3 days. Both groups received single dose preoperative antibiotic.(2) Results: Both groups were compared and there was no significant difference in rates of Surgical site infections between both groups. None of the patients developed intra-abdominal collection.(3) Conclusion: Single dose of postoperative antibiotic was sufficient in reducing surgical site infection after appendicectomy (5).