Smoking is an essential factor in coronary heart disease. In 2018, the total cost of coronary heart disease attributable to smoking at Cardiology B level in Rabat, Morocco was estimated at 2,446,402 MAD. Indirect costs accounted for 51% of total costs. More than 69% of direct medical costs are attributable to invasive treatment during hospitalization. The magnitude of the estimated cost highlights the urgent need for Morocco to implement comprehensive tobacco control measures to address these costs.