Solubility enhancement of allopurinol by solid dispersion using sugar carriers

The objective of research work is to enhance the solubility and dissolution of allopurinol by solid dispersion using different concentration of sugar carriers (lactose and mannitol). The allopurinol solid dispersions were prepared by kneading method using lactose and mannitol with different ratio of drug and carrier such as 1:1, 1:3, 1:5 and after the formulation all the physiochemical properties were examined. All the formulations were found within the permissible pharmacopoeial limits for various physicochemical parameters. The pre-formulation studies, like Fourier, transform infrared spectroscopy (FTIR) showed the absence of drug-excipient interactions. The solubility and dissolution profiles of the sample were increased with increasing the concentration of allopurinol solid dispersions. Kneading method was proved to be a successful technique for the development of stable solid dispersion of allopurinol. The dissolution amount percentage of allopurinol formulations was found between 89.43 to 98.43% within 60 min. Hence, from the all evaluation studies, it was evident that F5 formulation was the better formulation. F5 formulation (Allopurinol: Mannitol in the ratio of 1:3), 98.43% drug released within 60 min.