Background: Genetic diseases forms sizeable portion of diseases which being an important cause of morbidity and mortality, they impose a heavy burden on families and the health sector in our country. Thus Awareness about genetic diseases is crucial in today’s world. Aim and Objectives: To study awareness about genetic diseases among youth population in Akola city and to gain an insight into their understanding about it. Methodology: The cross-sectional study was conducted among 130 youths of Akola city in the month of March and April 2022. A predesigned pretested schedule was used to collect information on socio-demographic profile, knowledge, attitude and practices about genetic diseases was observed through interviews. Results: Majority of participants were male, 88.46% were in the age group of 20-30 years, 80% were studied graduation and above, 61.54% were students, 82.30% participants were aware about genetic counselling, 67.69% disagree that late marriages increases the risk of genetic diseases, 85.38% participants were interested to screen both themselves and their partner before marriage, 71.53% participants inquired about presence of genetic diseases in the family of person they wish to marry and 63.85% participants check blood group of partner before marriage, 91.53% participants accepted consanguineous marriage as a cause of genetic disease. Conclusion: Although majority of participants were educated and aware of genetic diseases, very few translated it in their daily practices. Pre-marital counselling and Screening should be made mandatory which in turn can reduce genetic diseases. Practical Application: This study can help to train and formulate policies and create awareness about Genetic diseases and can help them make better choices in their lives.