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Study of clinical and epidemiological profile in patients of Cerebral Venous Thrombosis in a tertiary care hospital in central India

Author: 
Dr. Alok Kumar, Dr. Neha Rai, Dr. Koustubh Rajgopal Bagul, Dr. Monika Porwal Bagul, Dr. Vinod Kumar Rai, Dr. Jasbeer Singh Kathpal, Dr. Dhanraj Panjwani, Dr. Archana Verma, Dr. Jignesh Dhameliya and Dr. Chetan Maniya
Subject Area: 
Health Sciences
Abstract: 

Aim: To study clinical and etiological spectrum for early diagnosis and management of CVT. To evaluate factors associated with poor outcome (mRS >2), prognosis and sequelae of CVT at 3 months follow-up. Methodology: A Retrospective and prospective observational study performed during 2011-2017 on patients diagnosed of CVT (radiologically confirmed by CTV/MRV) were included. Clinical profile including detailed history, onset, progression, risk factors, etiological spectrum, systemic examination and Routine investigations were done. Neurological status was assessed by mRS and NIHSS. Patients followed-up after 3 months personally/telephonically. Statistical software SPSS used for data analysis. Results: MC (52.8%) in young (21-40 years) patients with male preponderance (59.7%) with sub-acute onset (56.9%). MC site were deep sinuses 30 (41.7%) f/b superior sagittal sinus 29 (40.3%). Headache (79.2%) was MC presentation f/b seizures (51.4%). Hyperhomocysteinemia (37.5%) as MC risk factor, OCP use (34.5%) in females and alcohol (46.5%) in males. mRS was not dependent on clinical, etiological and hematological profile. There was significant decrease in mRS and NIHSS on discharge. Altered sensorium, Papilledema, motor deficit, mRS>2, low GCS, high NIHSS, elderly and low calcium predicted poor outcome. Good outcome in (80.56%), poor outcome in (19.4%) and 1 expired. Conclusions: CVT is rare treatable cause of stroke with varied presentation and risk factors. MC presentation is headache and seizure; MC risk factor is Hyperhomocysteinemia, OCP, alcohol. CVT has good prognosis if diagnosed earlier and treated promptly.

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