A total 453 Serum Samples from Women in Thamar with history of one or more unexplained abortion were screened for the presence IgG and IgM antibodies against Cytomegalovirus and Rubella virus by (ELISA). About 71 % (322/453) of the screened females were positive for either Cytomegalovirus or Rubella antibodies. Cytomegalovirus Ig M positive were (4.9 %) , Rubella IgM positive were (28.6 %) were positive CMV IgG (98.7 %) were positive Rubella IgG (27 %) ,and aborted women showed mixed infection with CMV IgM, with Rubella IgG. The rate of one miscarriage abortive women was 4.3 % (14/322) higher than to two and three miscarriage 1.5 % (5/322), 1.5 % (5/322), respectively.
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