The authors are commenting on the article entitled “A two-year study of diffused retinal pigment epitheliopathy treated with half-dose photodynamic therapy guided by simultaneous angiography and optical coherence tomography”published by Liu et al. in Eye 2019;33(5):737-745. The authors concluded that the best-corrected visual acuity was inversely significantly correlated with the ellipsoid and interdigitation zone and vision improvement may be attributed to the restoration of the outer retinal microstructures. However, the validation, extrapolation, and generalizability of the excellent outcomes of this study can be made only by regression analyses including all the missing baseline potential predictive factors mentioned by us in addition to the baseline characteristics already assessed.
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