Background: Perceived Organizational support would be influenced by various aspects of an employee’s treatment by the organization and would in turn, influence the employee’s interpretation of organizational motives underlying that treatment. Job satisfaction may get affected when the organizational climate becomes unhealthy at work place. How nurses perceive their organizational support and its impact on their job satisfaction to be explored as it may affects quality of patient care rendered and work life of nurses. Objectives: To assess the relationship between perceived organizational support and job satisfaction among nurses. Methods: A descriptive cross-sectional study was conducted among 40 nurses to assess the relationship between perceived organizational support and job satisfaction among nurses using perceived organizational support scale (POS) and Job Satisfaction survey in India. Results: The perceived organizational support score was 25.7± 3.8 and job satisfaction score was 136 ± 16.3. There was a significant positive co-relation between perceived organizational support and nurses job satisfaction (r = 0.24, p=0.04). Conclusion: Perceived organizational support is significantly associated with job satisfaction among nurses. Health care organizations should focus on strengthening the organizational support for nurses, henceforth the perception on organization could be positive and enhances nurse’s job satisfaction, reduce the intention to quit.