Design and development of curcumin loaded nanostructured lipid carriers for solubility enhancement

Poor solubility characteristics of curcumin limits its biological application though it possess various activities such as antioxidant, anti inflammatory, antifungal , antibacterial. This study describes the development of the curcumin loaded nano structured lipid carriers for the enhancement of solubility of the curcumin. Particle size is found to be 153.8 nm with a polydispersity index of 0.234 and entrapment efficiency 91.86± 12 and zeta potential 31.1 Mv. Besides the solubility enhancement and increased in vitro dissolution of the nlcs as compaired to drug curcumin is observed. The results of this study promises the curcumin nlcs enhance the drug solubility as well as biloavailability.