Evaluation Of Chlorpyrifos Induced Protein Metabolic Changes With An Emphasis In Different Tissues Of Mice

The literature pertaining to “pesticide protein interaction” contributes immensely to the field of pesticide biochemistry. The pesticides are found to be alter the structural and soluble proteins by causing biochemical changes in the cell. In the present study Healthy adult mice of same age (100±10 days) and weight (75±10 g) were divided into four groups having ten animals each. The second, third and fourth groups of animals were termed as experimental animals, To the animals of second group single dose of pesticide (i.e. on 1st day) was administered orally by gavage method. To the third group of animals double doses were given i.e. on 1st and 3rd day. Similarly multiple doses i.e., 1st, 3rd, 5th and 7th day were given to the fourth group of animals. The first group of animals was considered as controls. The experimental Mice exposed to chlorpyrifos showed statistically significant (P<0.01) decrease of total protein content, significant (P<0.01) increase of free amino acid (FAA) content, significant (P<0.01) increased of Aspartate aminotransferase(AST) activity and significant (P<0.01) increase of Alanine aminotransferase(AlAT) activity in heart, liver, kidney and muscle respectively. The activities was dose and time dependent manner in chlorpyrifos treated mice.