Aim: Postoperative inflammation is a known contributory factor in posterior capsular opacification. Ocular inflammatory response was studied by measuring micro protein levels in aqueous. Method: Aqueous tap was done during needling for PCO in 25 secondary cataracts. Equal number of age and sex matched cataract surgical cases were taken as controls. Results: Aqueous micro protein level was found to be higher in "after cataract" cases. Conclusion: This inexpensive method to study ocular inflammatory response was found to be helpful in prevention of posterior capsular opacification by using NSAIDs in all cases of Grade 1 PCO.