Association of vitamin d receptor bsmi polymorphism with susceptibility totuberculosis and types of tuberculosis infection among sudanese patients

Background: A case-control study was conducted to study vitamin D receptor VDR-BsmI polymorphism with tuberculosis (TB) susceptibility in the different types of tuberculosis infection among Sudanese patients. Methods: One hundred and twenty tuberculosis patients with 46 apparently healthy controls were included for genotyping of the VDR-BsmI polymorphism using Polymerase chain reaction and restriction fragment length polymorphism (PCR –RFLP). Results: This study found that the BsmI polymorphism in VDR gene is significantly associated with tuberculosis infection (P=0.00) and the heterozygous allele Bb is associated with susceptibility to tuberculosis infection with odd ratio 4.681. The pulmonary tuberculosis was the most predominant in the study population and it was found to be associated with the VDR-BsmI heterozygous Bb allele odds ratio (OR) 1.319 while the bb allele was associated with the Extra-pulmonary tuberculosis infections. Conclusion: The b allele is associated with susceptibility to TB infections among Sudanese patients especially to the extra pulmonary TB.