Objective: To explore the effect of evidence-based nursing on the quality of life of patients with gastric cancer. Methods: A total of 92 patients with gastric cancer were enrolled in our hospital. The patients were divided into two groups according to the admission time of the patients, 46 patients in each group. The control group received routine nursing, and the observation group used evidence-based nursing. The nursing intervention was 2 months, and the improved quality of life comprehensive assessment questionnaire was adopted. (GQOLI) compares the quality of life of the two groups of patients. Results: After 2 months of nursing, the psychological function, physical function, social function score and total score of the two groups were significantly higher than those before treatment, and the scores and total scores of the GQOLI scales in the observation group were significantly higher than those in the control group. Statistical significance (P <0.05). Conclusion: Evidence-based nursing can effectively improve the GQOLI scale score of gastric cancer patients and improve their quality of life. It has high application value in gastric cancer.