Bronchopulmonary dysplasia (BPD) is a common chronic lung disease in premature babies, especially those with very low body mass. Being a multifactorial disease, BPD requires complex pathogenetic, syndromnal, and symptomatic pharmacotherapy. In addition to oxygen therapy, it should include anti-inflammatory and antibacterial treatment, sparing prescription of glucocorticosteroids. It is also advisable to use antioxidants, proteinase inhibitors, drugs for the relief of apnea, diuretics. When prescribing pharmacotherapy, it is necessary to take into account the severity of the disease, the development of complications, the tolerance of drugs, the therapeutic response of the infant’s body to treatment. However, the effect of treatment can vary from very good to extremely weak.