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4-Cyano-1,3-oxazole-5-sulfonamides as Novel Promising Anticancer Lead Compounds

Author:

Maryna V. Kachaeva, Stepan G. Pilyo, Bogdan A. Demydchuk, Volodymyr M. Prokopenko, Victor V. Zhirnov and Volodymyr S. Brovarets

Subject Area:

Physical Sciences and Engineering

Abstract:

The available 2-acylamino-3,3-dichloroacrylonitriles when treated by sodium hydrogen sulfide undergo cyclization into the 4 cyano-1,3-oxazole-5-thioles. These latter compounds were converted into the 2-aryl-4-cyano-1,3-oxazole-5-sulfonamides using a standard reaction sequence. Synthesized compounds were screened for anticancer activity against a panel of 60 cancer cell lines at the National Cancer Institute, USA.

PDF file:

30604.pdf

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