The available 2-acylamino-3,3-dichloroacrylonitriles when treated by sodium hydrogen sulfide undergo cyclization into the 4 cyano-1,3-oxazole-5-thioles. These latter compounds were converted into the 2-aryl-4-cyano-1,3-oxazole-5-sulfonamides using a standard reaction sequence. Synthesized compounds were screened for anticancer activity against a panel of 60 cancer cell lines at the National Cancer Institute, USA.