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Abnormal liver enzymes (alt & ast) and incidence of three vessel coronary arteries disease

Author: 
Sakher Alsharaa, Dawood Alkhalaileh, Hassan Elqaderi, Khalil Musallam and Yazan Bani Hamad
Subject Area: 
Physical Sciences and Engineering
Abstract: 

Objective: A lot of Recent studies try to investigate the relationship between abnormal liver enzymes aspartate aminotransferase (AST), alanine aminotransferase (ALT) and incidence of coronary arteries disease. In this study we try to find a relationship between abnormal liver enzymes and three vessel coronary arteries disease. Method: One-hundred coronary arteries disease patients were randomly chosen from those who followed in outpatient clinic from Jan 2022 to June 2022 in queen alia heart institute. After reviewing angiography reports, patients were divided into two groups as three vessel CAD and non-three vessel CAD, non-three vessel CAD group also divided into 1-2 vessel CAD and medical CAD. In addition to optimal medical therapy and revascularization (percutaneous coronary intervention, coronary artery bypass grafting), measurements of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) concentrations were performed in all patients before proceeding with coronary angiography. Results: The patient groups of CAD distribution were 13% medical CAD, 62% 1or 2-vessel CAD and 25% 3-vessel disease. Mean age was 63.48 ± 11.833 (range 33–87) years and 22 per cent (n = 22) were females. 49% them are diabetic and 72% are hypertensive patients. 5% of patients have elevated AST (>37) & 5% have elevated ALT (>41). All of them didn’t show elevation > 3-folds of normal. None of the elevated enzymes patients found in the 3-vessel CAD group. Conclusion: abnormal liver enzymes aspartate aminotransferase (AST), alanine aminotransferase (ALT) may not be associated with angiographic severity of coronary arteries disease.

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