Hypertriglyceridemia is a rare cause of Acute pancreatitis up to 10% cases. In treatment, pancreatic rest, lifestyle changes, medications (fibrates, n-3 polyunsaturated fatty acids, and nicotinic acid) are essential. Many experimental treatment modalities have been reported as insulin and heparin infusion and plasmapheresis. In this study we present the hypertriglyceridemia-induced acute severe pancreatitis with multi-organ dysfunction which had not been reported in the past.