Objective: The objective of the study was to contribute to the literature by investigating how HIV spread differ with the demographics, and socio-economic factors among the population in Zambia. Introduction: Sothern Africa is considered worst affected by Human Immunodeficiency Virus (HIV) and still home to an estimated 6.3 million people living with HIV in 2013. In an attempt to determine the factors that associated with HIV we investigated the demographic and socio economic elements. Methods: In order to estimate the infection of HIV and its associated risk factors using Zambia ZDHS 2014 survey data, the univariate and multivariate logistic regression analysis were applied. Results: The models showed that marital status, residence type, education level, wealth index were statistically significant. Where having electricity, television, radio, and using internet were not positively associated with HIV prevalence. With 83058 respondents from the Zambia Demographics and Health Survey (ZDHS) the HIV test showed higher percentage of HIV infection of 6.4% for female than male (3.6%). Conclusions: In order to prevent the infection from increasing continuous investigation of the transmission determinants is needed. The outcome of this study will help the policy maker to update their current knowledge of HIV infection for an effective prevention program.