Assessments of il-20 levels present in salivary and gingival crevicular fluid in non-smoker chronic periodontitis patients

Background: Chronic periodontitis is inflammation of the tissues surrounding tooth structure. Several cytokines are involved in pathogenesis of periodontitis. For example, IL-20 promotes inflammation, angiogenesis, chemotaxis and regulates osteoclast differentiation. Objectives: the purpose is to evaluate the IL-20 levels found in salivary and gingival cervicular fluid (GCF) in healthy and chronic periodontitis patients. Methods: GCF and Saliva samples obtained from systematically free adult individuals. They were divided into ten patients with moderate and severe chronic periodontitis and ten periodontally healthy subjects. The GCF and saliva samples from chronic periodontitis patients were collected before and after nonsurgical periodontal therapy. All GCF and saliva samples were stored at -80°C till laboratory analysis. IL-20 levels were measured by ELISA according to manufacturer instructions. Results: IL-20 levels were significantly higher in patients with chronic Periodontitis compared with healthy periodontal patients (T=2.712, P≤0.010). However, the levels of IL-20 reduced after non surgical Periodontal treatment, but this difference was statistically insignificant (T=1.859, P≤0.079). Conclusions: We have shown that IL -20 may play a role in Chronic Periodontitis patients.