A helical coiled heat exchanger is generally functional in industrial applications due to its compact structure, larger heat transfer area and higher heat transfer capability. The study of this investigation is the comparison CFD Analysis of TiO2 Nano-Fluid with Water and Ethylene Glycol as a base fluid in Tapered Helical Coil Heat Exchanger with the help of CFD on copper tube. The Titanium Oxide (TiO2), are used as Nano fluid and water and ethylene glycol is a base fluid. Tapered Helical coil was fabricated by bending 500 mm length of copper tube having 10mm tube diameter, 50mm pitch coil diameter, 20mm pitch and 20 tapered angle. The comparison of pressure drop and temperature variation between TiO2 nano fluid with water as its base and TiO2 nanofluid with ethylene glycol as its base is found in this analysis. The result indicates that the TiO2 nanofluid with ethylene glycol as a base fluid have maximum pressure drop and TiO2 nanofluid with water as its base fluid have maximum temperature variation compare with ethylene glycol as a base fluid. A computational fluid dynamics (CFD) methodology using ANSYS FLUENT 15 is used here to investigate pressure drop of Titanium Oxide (TiO2) nanofluid with ethylene glycol and water as its base fluid on the heat transfer characteristics in a tapered helically coil-tube.