Correlation between the degree of disease activity in rheumatoid arthritis with serum uric acid in patients at wahidin sudirohusodo hospital makassar and its network

Introduction: Rheumatoid arthritis (RA), is a chronic autoimmune disease characterized by progressive joint damage, with very high morbidity and mortality. High level of serum uric acid is associated with a condition of ischemic injury, and aggravate the inflammatory process in RA, it is suggested that uric acid is associated with the degree of disease activity in RA. Aim: Determine the correlation between the degree of disease activity in rheumatoid arthritis with level of serum uric acid in patients treated in Wahid in Sudirohusodo hospital Makassar and its network. Method: This research is an observational type with cross sectional approach in 57 subjects of rheumatoid arthritis, who were over 18 years old and did not have other autoimmune diseases. The degree of disease activity was assessed based on DAS28-LED instrument. Serum uric acid, serum creatinine, erythrocyte sedimentation rate (ESR) test, using venous blood samples. Sampling is done consecutive sampling and put into the experiment until a certain time so that the number of sample reached. Methods using Multiple and logistic regression to determine the relationship between the degree of rheumatoid arthritis disease activity and serum uric acid levels. Result: In this study most were 40-59 years old (43.9%), with the most subjects were females (73%), and most with high degree of disease activity (52.6%). Based on regression and multivariate analysis, male sex was most significantly correlated with uric acid level (p <0,05), there was no significant correlation between degree of disease activity and serum uric acid level. Conclusion: There were no significant correlation between the degree of rheumatoid arthritis disease activity and serum uric acid levels, though it may appear that the uric acid levels increased at higher levels of activity. Risk factors most significantly associated with serum uric acid levels is the male gender. Further research is needed with larger sample quantities and longer time, to be able to assess fluctuations in serum acid levels, and to assess other risk factors affecting serum uric acid levels.