Introduction: Aim of the study to evaluate the association between facial morphology and various depths of curve of spee and variations in males and females in South Indian population. Methods: 96 diagnostic casts and lateral head cephalograms of selected subjects on the basis of depths of curve of Spee as measured on the mandibular casts were selected. The subjects were divided into three Groups (Group-I- 0-2 mm, Group -II >2-4 mm and Group-III >4 mm of curve of Spee), (n=32, m=16, f=16) and further into subgroups according to sex. Cephalometric and study cast variables were measured and subjected to statistical analysis with curve of Spee as the dependent variable and others as independent variables. Results: SNB, APDI, L-E line were negatively correlated and ANB, ODI,G-SN-POG were positively correlated with depth of curve of Spee in both males and females. Conclusion: Various parameters in the facial morphology contributes to the curve of spee. This, will be helpful in diagnosis as well as determination of this relationship is useful to assess the feasibility of leveling the curve of Spee by orthodontic treatment.