Myocardial infraction is characterized by necrosis of heart cells because it doesn’t get enough blood flow to heart due to blockage of blood clots. Depression is one of the common, frequent complications occur after an attack of myocardial infraction, its impact affects long term quality of life to a higher incidence of mortality of myocardial infarction patients. Thus, the present consensus statement aims to provide an overview of the prevalence, risk factors associated with depression followed by a myocardial infarction, impact of depression in a myocardial infarction patient, diagnosis and its treatment options. Overall research studies show that patients with myocardial infarction have higher risk of all-cause mortality, cardiac mortality and recurrence of cardiac events if they have post-myocardial infraction depression. The patients with history of either myocardial infarction or depression, complication that occurs during hospitalization, patients with infirm social relationships, biological imbalance and physical illness are the contributing risk factors of depression among myocardial infarction patients. Future studies are required to find out the exact relationship between depression and myocardial infraction. Selective Serotonin Receptor Inhibitors are the better drug of choice among all anti-depressive drugs. Cardiac rehabilitation is also very effective. Early diagnosis and management of depression after myocardial infarction attack take the edge of future complications.