The twenty first century witness the trait by substance and illicit drug abuse consider as a global challenging problem. According to the drug and crime (UNODC) estimated about seven percent of the global population between the 15-64 age group has been using an illicit substance almost in all developing and developed countries suffering with the greatest burning problem of drug users among youth. The risk factors for the illicit drug abusers may be having biological pre-disposition to drug abuse personality traits the reflect a lack of social bonding, low status of family, family relations, parental care, neglected defective emotional and psychiatric problems, stress and other problems among the youth in the world and particularly in the country like India. The concept of illicit drug abuse, drug addictions and abstinence syndrome need some clarity. In the sociological context drug is a term of habit-forming substance which directly effect upon the human body. So, illicit drug and substance abuse leads to physical and psychological health problems and effect on the youth in all over the world. Those using the drugs are just doing it for crazy experiment and for showing social status using while they are in the youth stage and sometimes it is very common to take some local drugs to relieve stress and to get rid of the psychological problems. It is a high to raising awareness about the consequences of substance use and the problem of health deterioration among youth.