Nowadays popularity of using energy drinks is more common but quality used in these energy drinks has either detrimental or benefits on organisms fitness. Present study was carried out D.melanogaster to study effect of synthetic and natural energy drink on longevity. Here the larval feeding rate and adult longevity were studied and it revealed that, flies fed on natural energy drink had consumed greater quantity of food and lived significantly longer compared to flies grown in synthetic energy drink and normal food media. This shows that the nutrients present in the natural energy drink had played a vital role in increasing life span of the fly. Thus these studies suggests that consumption of natural energy drink is more beneficial over synthetic energy drink in D.melanogaster.