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Effect of metoprolol on hepatic ischemia-reperfusion injury

Author:

Silvio Marcio Pegoraro Balzan, AlexandreRieger, ViníciusGrandoGava, Daniel Pra, Pedro Lúcio de Souza, Rafael AntoniazziAbaid, DanieliRosaneDallemole and Caio Fernando de Oliveira

Subject Area:

Health Sciences

Abstract:

Purpose: Beta-blockers show promise in the attenuation of ischemia reperfusion during cardiac surgery, however its role on injury during liver surgery is not known. Methods: This preclinical study evaluated the use of beta-blockers during induction of anesthesia in a swine model of liver ischemia-reperfusion injury (metoprolol and control groups). Results: A total of 28 animals were studied and no difference was observed between groups in biochemical markers sampled before and after liver ischemia and reperfusion. Conclusion: The use of beta-blockers does not have a clinical impact on attenuating liver ischemia reperfusion injury.

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