The Effect of Probiotics, Oregano Oil and Quillaja saponaria on Isolated B. hominis: An experimental view

Diabetes is very common disease in Pakistan and abnormalities in lipid profile is one of the most common problems. Many oral hypoglycemic are available for the treatment of diabetes mellitus. This study is conducted on drug which is used for the management of diabetes that is Dipeptidylpeptidase-4 inhibitor, Sitagliptin. In this study hypolipidemic effect of combination of sitagliptin and Szygium cumini seed is compared with sitagliptin alone administration. The effect of drugs was observed on diabetic rabbit models. In animal models diabetes was induced by induction of alloxan. In comparision of combination of sitagliptin and Szygium cumini seed effects were examined on the levels of cholesterol, triglycerides and plasma lipoproteins (HDL, LDL and VLDL). It may be concluded that cholestrol HDL ratio, triglyceride, VLDL value reduced in combination as compared to sitagliptin alone in which these values are increased, that is dangerous for health. HDL reduced in sitagliptin alone but in combination, its value increased that is a good marker.