Introduction: Resistance training is also known as strength training. Strength training programmes may include the use of free weights, weight machines, elastic tubing, or body weight. In preadolescents proper resistance training can enhance strength without concomitant muscles hypertrophy. This mechanism helps to explain the strength gained from resistance training in population with low androgen levels including males and females. Strength training can also augment the muscles enlargement that is normally acquired with pubertal growth in males in females. Purpose: To achieve the purpose of these study 30 male handball players were selected from Alagappa matric Higher Secondary School, karaikudi. Random group design was used. The subject’s age ranged from 14 to 17 years. Methodology: To carry out the study the investigator used two groups, one experimental group and one control group, each group consists of 15 subjects. All the groups were tested after the training on Half squat, leg press, leg extension, leg curl, upright rowing, bench press, abdominal curl, shoulder press, seated calf rise with the intensity of 65% and duration of 30 seconds 9 repetition of 3 sets each with rest interval period of 10 seconds was given to the subjects, selected criterion variable and the readings were recorded in their respective unit, as pre-test scores. After pre-test the experimental group was treated with resistance training for a period of six weeks. After six weeks of training both the groups were tested again on the selected criterion variables and the scores were recorded in their respective units as post test scores. The pre and post test were taken for analysis. The followings statistical procedure was followed to estimate the effect of resistance training on speed, explosive power, and breath holding time of higher secondary school handball players. Statistical technique: The data collected from the subject on selected physical and physiological variables were statistically analyzed by using ‘t’ ratio, 0.05 level of confidence was fixed to test the level of significance. Conclusion: The study concluded that Speed, Explosive power on Breath holding time, were significantly improved to the influence of resistance training group among higher secondary school handball players.