Effect of vitamin d3 on improvement of patients aged 18-65 with treatment resistant depression (TRD)

The aim of this study was to investigate the effect of vitamin D3in response to the treatment ofstage1treatment-resistant depression. In this clinical trial, 64 patients with treatment-resistant depression in the age range 18-65yearsreferred to Ziaeian Hospital were enrolled. Patients were randomly divided into two groups of 32 patients in each group and in addition to the main treatment for depression, in group A, vitamin D was administered and group B, received placebo of vitamin D. There were no statistically significant differences in the levels of alkaline phosphatise and phosphorus in group A and B before and after taking vitamin D or placebo. The parathyroid hormone inpatients receiving vitamin D were reduced, although this reduction was not statistically significant. The average level of vitamin Din patients taking these vitamins significantly increased. The results of this study showed that patients who had received vitamin D, their depression were quite improved and while the average depression score of patients receiving placebo was moderate at the end of the study. Since depression is accompanied by decreased serum level of vitamin D, consumption of supplementary vitamin D can be helpful in the treatment of these patients.