Evaluation of haemostatic changes among chronic liver disease Sudanese patients with hepatitis c infection

Hepatitis C virus (HCV) infection is a common global public health problem. HCV is considered as the main cause of chronic liver diseases. In patients with liver disease, substantial changes within the haemostatic system are frequently observed. This study aimed to evaluate haemostatic changes among chronic liver disease patients due to hepatitis C infection in Sudan. The study included 97 patients, their fibrinogen levels, PT, APTT, TT, platelets count and liver function tests were measured and compared with 50 healthy subjects as controls. Mean fibrinogen level (443.37±59.00 mg/dl), mean PT (24.22±9.09 seconds), mean APTT (43.60±4.48 seconds) and mean TT (23.09±6.11 seconds) were significantly higher among patients than the controls (p 0.000 for each parameter). Mean platelets count (100.89±29.26X109/L) was significantly low among patients, when compared with the controls (p value 0.000). The study showed a significant association between fibrinogen levels and ALP (p value 0.043). There was no significant association between fibrinogen level and the other liver function tests. In conclusion, our study observed haemostatic changes with higher fibrinogen level, lower platelets count and prolonged PT, APTT and TT among the study group than the controls.