Safe, effective and ethical medication practice is an important component of client care, an evaluative study was conducted to assess the performance of staff nurses regarding administration of IV medication in Guru Teg Bahadur Sahib (C) Hospital, Ludhiana, Punjab. Sixty nurses were observed while administering medications by using a checklist based on Donabedian’s -structure, process, outcome framework. Results showed that overall performances were lower than the expected standard and therefore needed improvement to reach upto expected standards. There were deficits in performance of nurses related to criteria of structure standard i.e. availability of articles, process standard i.e. interventions, after care of articles, evaluation and outcome standard i.e there is no extravasation, there is no phlebitis and patient is comfortable.