This study aimed to determine the differences in immunohistochemical expression of Interleukin-8 (IL-8) in women with pelvic organ prolapse and without pelvic organ prolapse. This research was an analytical study of 2 unpaired study subjects with cross sectional design by conducting immunohistochemistry examination of interleukin 8 (IL-8) in paraffin blocks of sacrouterine ligament tissue in women with and without pelvic organ prolapse at Haji Adam Malik General Hospital Medan in January to February 2017. Most of the subjects in pelvic organ prolapse group were more than > 60 years old, mutipara, and had menopause. Most of them having pelvic organ prolapse grade 3. From the results of data analysis, a significant relationship was found between menopausal status with IL-8 expression based on Allred scores. There were also a significant relationship found between parity and IL-8 expression based on Allred scores with statistically significant differences between IL-8 expression based on Allred scores in pelvic organ prolapse group versus non pelvic organ prolapse.
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