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Formulation of combination of wuluh starfruit gel extract (averrhoa bilimbi.l) and papaya leaf extract (carica papaya) as antibacteriacauses of acne

Author: 
Husni Hasri Yanto, Anny Victor Purba and Shirly Kumala
Subject Area: 
Life Sciences
Abstract: 

Acne sufferers sometimes hate themselves, away from interpersonal relationships. This disease is triggered by the bacteria Propionilbacterium acne, and Staphylococcus aureus. Various acne treatments are offered in the community, but not all acne drug products are guaranteed safe. The purpose of this study was to obtain an acne gel preparation, a combination of extracts of star fruit and papaya leaves which have antibacterial activity against Streptococcus aureus and Propionibacterium acnes To determine the compounds that have antibacterial activity, bioautography using GCMS analysis was carried out. The preparation was made by mixing carbophol 940, triethanolamine, methyl paraben, propylene glycol, sodium metabisulfite. The results of the evaluation of the preparation at room temperature storage did not experience significant changes and were relatively stable, while at hot and cold temperatures there was a slight change in pH, dispersion, viscosity and flow properties. Peaks include 1,3-Diacetoxy-butane, 1-Pentanamine, Pentadecanoic acid, 9-Octadecenoic acid, and 1,2-Benzenedicarboxylic acid.Formula 3 has almost the same stability as formula 1 and formula 2. Formula 3 has room temperature storage for 3 months, including: organoleptic preparations dark brown in color, slightly entangled homogeneous, pH 5.11 preparations, spreadability of preparations 2628.01 mm² viscosity of preparations 79666, 67-258333,33 cPs flow properties 184466,33- 286282,17 cPs, the results of the antibacterial activity showed the Inhibitory Diameter (RD) on P acnes 14,56±0,1131 mm and S aureus 15,18±0, 0424mm . The formula was non-irritating to test animals.

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