Background: The medical store is one of the most extensively used facilities of the hospital. Approximately 35% of annual hospitals budget is spent on buying materials and supplies, including medicines and hence it is essential that health managers use scientific methods to achieve efficient management and patient satisfaction. Aim and objectives: To apply Selective Inventory Control techniques for the drugs used in Intensive Care Unit of Tertiary care teaching hospital. Materials and methods: The annual consumption and expenditure incurred on each item of controlled drugs in Medical ICU for the year 2013-14 was analyzed and inventory control techniques, i.e. ABC, VED and ABC-VED matrix analysis, were applied. Results: It was observed that 14 medicines (43.33%) out of 30 were classified in the category1(AV+BV+CV+AE+AD) for stringent control. Conclusion: Scientific inventory control management to be applied for efficient management of medical stores.