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Management of fatigue – a narrative review of proposed interventions and their effectiveness

Author: 
Tingshan Yan, Manisha Oberoi, Ayman Askari, Hana Morrissey and Patrick Ball
Subject Area: 
Health Sciences
Abstract: 

Introduction: Fatigue is a significant and frequently encountered health complaint that may accompany many medical conditions, communicable and non-communicable. Long-Covid is increasingly presenting to general practice and specialist neurology and rheumatology clinics which in most cases involves elements of CFS causing sudden increase in the patients seeking solutions for chronic fatigue. Results: There are many supplements offered commercially for the treatment of fatigue. Some are categorised as complementary or traditional medicines and are not licensed or controlled as medicinal products. Of those licensed as medicines, many are not licenced for the treatment of fatigue, so are prescribed ‘off-label.’ Patients have reported variable experiences with the different supplements and medications discussed. This paper attempts to document the available evidence for their efficacy in the treatment of fatigue. Conclusion: In almost all cases, only some patients derive any benefit and the benefits found are marginal culture RCT comparative studies using standardised products from those listed in this review are required to be able to make a definitive conclusion.

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