The paper discusses the immunosuppressive effects of pharmacological drugs. The task is to reduce the possible side effect of drugs due to annually increasing public access to medicines as a result of a large number of OTC drugs available for sale accompanied by a lack of objective information about their possible negative consequences. Here, we present information on the study of immunosuppressive effects of various pharmacological groups and their impact on public health. To a certain extent, this information allows predicting the effect of drugs on the body’s responsiveness, and their contribution to aggravation or elimination of initial immune disorders in patients.