Outcomes of gemmo-modified plant combinations against chronic hypertension and tachycardia

Five common Pakistani plants Allium sativum, Allium cepa, Zingiberofficinale, Terminaliaarjun aand Moringaoleifera were used to prepare two polyherbal formulations 5G and 5N for the treatment of chronic hypertension and tachycardia. Both the treatment combinations were applied on the healthy rabbits in the phase-I. Histopathology of rabbits organs revealed no side effect by any of the two combinations. DPPH assay indicated the superiority of 5G combination over 5N due to its higher antioxidative potential. Hence, the 5G combination (alone and in combination with inderal) was applied on 33 humans facing chronic hypertension and 36 chronic tachycardia patients in the phase-II of the study. Findings revealed the greater medicisnal potential of 5G + inderal as compared to inderal and 5G alone. 5G + inderal lowered the mean diastolic blood pressure to 74.36+3.21 mm Hg from 94.24 ± 1.66 mm Hg and mean systolic blood pressure to 128.79+3.17 mm Hg from 194.44±2.07 mm Hg. Mean pulse rate was reduced from 115.00±1.04 beats/min to 75.58±4.36 beats/min after treatment with 5G + inderal.