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Pattern of hematological disorders on bone marrow examination: a study of 130 cases

Author: 
Dr. Isma Niyaz, Dr. Riyaz Ahmed Tasleem, Dr. Humaira Bashir, Dr. Nazia Bhat, Dr. Neelofar Gul, Dr. Bilal Musharaf Banday and Dr. Samina Kanday
Subject Area: 
Health Sciences
Abstract: 

Bone marrow examination is the simplest, cheapest and most reliable method to diagnose most of the malignant and non malignant hematological disorders in a short span of time. The aim of this study was to evaluate the pattern of hematological diseases diagnosed by bone marrow examination among patients with suspected hematological disorder .This was a prospective study conducted on bone marrow aspirations and biopsies performed from 1st April 2013 to 30th September 2014. A total of 130 bone marrow aspirations + biopsy were studied during this time period. Age ranged from 15-80 years. There were 68 females and 62 males with female to male female ratio of almost 1:1. The most frequent indications for bone marrow examination were unexplained anemia or pancytopenia found in 80% of request forms. The most common hematological disorder encountered was anemia accounting for 62.3% of all cases. This was followed in order of frequency by acute leukemias (9.23%), plasma cell dyscrasias (6.92%), lymphoproliferative disorders (6.15%), Myeloproliferative disorder (6.15%), platelet disorders (3.84 %), and Myelodysplastic syndrome (2.3%). In addition metastatic deposits of adenocarcinoma were observed in 1.5% cases. The study provided a valuable insight into the pattern of involvement of bone marrow by various hematological disorders in our community.

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