Anticoagulant drugs are commonly prescribed to patients with atrial fibrillation, pulmonary embolism, deep vein thrombosis, venous thromboembolism, congestive heart failure, stroke, myocardial infarction, genetic or acquired hypercoagulability, prosthetic heart valves and cardiac stents placement. On the other hand, this may increase the risk of bleeding during invasive dental surgical procedures. This article briefly reviews on perioperative guidelines and management of dental patients receiving oral anticoagulant drugs.