The different parts of neem tree contain various active compounds which are rich in antibacterial activity. The present study highlights the phytochemical analysis of neem seed. Various bioactive compounds like alkaloids, flavonoids, coumarin, leucoanthocyanin etc., were present in aqueous and acetone extract of neem seeds. A soap must cleanse the body properly without disturbing thepH level of the skin. As per the results and discussion of the present study, neem seeds contain antibacterial activity and it also has appreciable quantity of oil. So preparing the soap using neem seed destroys the microorganism which keeps our skin safe and healthy. The homemade neem soap can be replaced with other synthetic soaps for better results