Demarcated opacities are the developmental defects characterised by insufficient mineralization in enamel. The defects exhibit clinically as a creamy-white demarcated opacities ,yellowish brown to macroscopic loss of tooth structure. The Aim of this study is to evaluate the demarcated opacities in 12-15 years children using different forms of asthma drug. METHODS: A cross sectional study carried out in SMS Hospital Jaipur, children aged 12-15 years ( n= 124) having asthma were included in the study, they were further divided into four groups according to form of asthma drug they were consuming i.e., through Oral route, Inhalation, Parental and consuming drug in any of the above combination( Oral + Inhalation, Inhalation + Parental, Oral + Parental) Modified Developmental Defect Index was used for recording the enamel opacities. RESULTS: Among 124 children 71 were males and 53 were females, the mean age of children was 13.4 years, the mean duration of asthma was 3.6 years for children consuming corticosteroids, 3.5 years for children inhaling and 3.8 years children consuming orally. High prevalence of demarcated opacities in upper right central incisors i.e. 71.1 % children and 72.6 % children with upper left central incisors. Thus it was concluded children using asthma drug through oral route had decreased prevalence of demarcated opacities when compared to children consuming asthma drug in combination and using corticosteroids. Thus the both mandibular molars exhibit other defects i.e. Dental Caries and Macroscopic loss of tooth structure