Maxillary defects could be due to multiple reasons such as tumors, trauma and congenital defects. Rehabilitating such defects can be difficult at times as it encounters problems like inadequate retention, loss of lips and cheek fullness, poor appearance and psychologic disturbance to the patient. This case illustrates an acquired maxillary defect and the aim of this case report was to describe the prosthetic management of a patient who had undergone surgery for ameloblastoma of the maxilla. The maxillofacial prosthodontist faces a challenge to restore the functions, aesthetics as well as the speech of the patient. In this case a cast partial prosthesis was fabricated by carefully identifying the problems in hand and reconstructing the lost tissues. This method was time saving and beneficial to the patient.