CERTIFICATE

IMPACT FACTOR 2021

Subject Area

  • Life Sciences / Biology
  • Architecture / Building Management
  • Asian Studies
  • Business & Management
  • Chemistry
  • Computer Science
  • Economics & Finance
  • Engineering / Acoustics
  • Environmental Science
  • Agricultural Sciences
  • Pharmaceutical Sciences
  • General Sciences
  • Materials Science
  • Mathematics
  • Medicine
  • Nanotechnology & Nanoscience
  • Nonlinear Science
  • Chaos & Dynamical Systems
  • Physics
  • Social Sciences & Humanities

Why Us? >>

  • Open Access
  • Peer Reviewed
  • Rapid Publication
  • Life time hosting
  • Free promotion service
  • Free indexing service
  • More citations
  • Search engine friendly

Proteases and antiproteases new potential biomarkers/variables for polytrauma survival modeling? a pilot research

Author: 
Oleg Arnaut, Ion Grabovschi, Ruslan Baltaga and Serghei Sandru
Subject Area: 
Life Sciences
Abstract: 

Background: Despite big progresses in early management of trauma patients, traumas still represent an actual subject at international scale being the main cause of death for persons younger than 44 years. Polytrauma is the most unexplored and unsearched category of traumas. There is no international consensus according the most efficient scale, many of them returning different results in estimating the patient’s condition complications and patient’s mortality risk in case of trauma. The described situation makes us to search some solutions inclusively new factors with a higher predictive power in estimating the polytrauma patient’s outcomes. We supposed that such an instrument could be different protease/antiprotease system’s components. Objectives: The aim of this research was to estimate the predictive potential of proteases and antiproteases by polytrauma population survival rate modeling. Methods: In a prospective pilot study, 65 polytrauma patients admitted in acute period of trauma were analyzed. Plasma samples were collected at 3, 6, 12 and 24 hours after traumatic impact. We measured the values of two antiproteases concentration and enzymatic activity of six proteases. In order to identify the potential biomarkers for survival rate, we have compared proteases/antiproteases system components between survived and non-survived patients. The evidenced potential biomarkers were used for regression analysis modeling, discrimination, determination and calibration characteristics being estimated. In addition, the resampling procedure for model’s stability estimation was applied. Results: The comparative evaluation among evidenced molecular phenotypes in survived and non-survived patients allows to consider a seria of primary outcome potential biomarkers/predictors. The outcome modelling by regression analysis used these potential predictors. Finally, five parameters, especially α2M3, CDEA3, ARDS, α2M6, CHEA6, EEA3 and CGEA12, were the components (efficient variables) from models that predict the survival rate using their values at 3, 6 and 12 hours after the trauma, results being adjusted to age, gender and ARDS diagnosis. Conclusions: In our research, we estimated the predictive potential of different protease/antiprotease system’s components for polytrauma population. Using this data, three predictive models were obtained. Without any doubts, they can be used in clinical practice after validation and improvement by including more variables in equation. The identified survival prediction biomarkers could be used as base stones of potential therapeutic strategies

PDF file: 

CALL FOR PAPERS

 

ONLINE PAYPAL PAYMENT

IJMCE RECOMMENDATION

Advantages of IJCR

  • Rapid Publishing
  • Professional publishing practices
  • Indexing in leading database
  • High level of citation
  • High Qualitiy reader base
  • High level author suport

Plagiarism Detection

IJCR is following an instant policy on rejection those received papers with plagiarism rate of more than 20%. So, All of authors and contributors must check their papers before submission to making assurance of following our anti-plagiarism policies.

 

EDITORIAL BOARD

CHUDE NKIRU PATRICIA
Nigeria
Dr. Swamy KRM
India
Dr. Abdul Hannan A.M.S
Saudi Arabia.
Luai Farhan Zghair
Iraq
Hasan Ali Abed Al-Zu’bi
Jordanian
Fredrick OJIJA
Tanzanian
Firuza M. Tursunkhodjaeva
Uzbekistan
Faraz Ahmed Farooqi
Saudi Arabia
Eric Randy Reyes Politud
Philippines
Elsadig Gasoom FadelAlla Elbashir
Sudan
Eapen, Asha Sarah
United State
Dr.Arun Kumar A
India
Dr. Zafar Iqbal
Pakistan
Dr. SHAHERA S.PATEL
India
Dr. Ruchika Khanna
India
Dr. Recep TAS
Turkey
Dr. Rasha Ali Eldeeb
Egypt
Dr. Pralhad Kanhaiyalal Rahangdale
India
DR. PATRICK D. CERNA
Philippines
Dr. Nicolas Padilla- Raygoza
Mexico
Dr. Mustafa Y. G. Younis
Libiya
Dr. Muhammad shoaib Ahmedani
Saudi Arabia
DR. MUHAMMAD ISMAIL MOHMAND
United State
DR. MAHESH SHIVAJI CHAVAN
India
DR. M. ARUNA
India
Dr. Lim Gee Nee
Malaysia
Dr. Jatinder Pal Singh Chawla
India
DR. IRAM BOKHARI
Pakistan
Dr. FARHAT NAZ RAHMAN
Pakistan
Dr. Devendra kumar Gupta
India
Dr. ASHWANI KUMAR DUBEY
India
Dr. Ali Seidi
Iran
Dr. Achmad Choerudin
Indonesia
Dr Ashok Kumar Verma
India
Thi Mong Diep NGUYEN
France
Dr. Muhammad Akram
Pakistan
Dr. Imran Azad
Oman
Dr. Meenakshi Malik
India
Aseel Hadi Hamzah
Iraq
Anam Bhatti
Malaysia
Md. Amir Hossain
Bangladesh
Ahmet İPEKÇİ
Turkey
Mirzadi Gohari
Iran