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Quality control tests of different available brands of levofloxacin and ofloxacin in the market of quetta city

Author: 
Rehmatullah Khan, Ghulam Razaque, Ghulam Mustafa Shahwani, Noman Ul Haq, Nisar Ahmed Shahwani, Muhammad Arsalan, Raseed Ahmed, Abdul Ghaffar, Naila Masood and Abdullah
Subject Area: 
Health Sciences
Abstract: 

Levofloxacin is a third generation fluoroquinolones antibiotic with a broad spectrum activity against different kinds of bacteria. It is very widely used antibiotic, Levofloxacin has activity that is to counter the production the bacteria by damaging the DNA gyrase enzyme responsible for the replication of the bacteria to avoid further multiplication of bacteria. Ofloxacin is widely used broad spectrum fluoroquinolones antibiotic used against variety of bacterial infections caused by gram negative and gram positive bacteria. Ofloxacin is an intermediate between ciprofloxacin and norfloxacin in activity against gram negative bacteria but it is comparable to or more potent than Ciprofloxacin for gram positive bacteria and certain anaerobes. Quality control is a system in which we make sure that the products are formulated and Quality control checked according the given standards. It will help in avoiding the risks involved in a Pharmaceutical industry that cannot be countered by simple testing of the product. Different brands of Ofloxacin and levofloxacin were collected from the market of Quetta Pakistan. Checked physiochemical properties of all collected brands of Levofloxacin and Ofloxacin and compared with each other according to the standard protocols. The physiochemical tests were performed weight variation, Hardness, Friability, Thickness, Disintegration and Dissolutions. The results showed that the all brands were within acceptable range including the dissolution of the both formulations tested. It is concluded that these type of research may be conducted in future to check the Quality control tests of available brands of different formulations. These types of research will contribute the community for the best selection of the medicine from the market and also help the prescriber to select a best drug among the available formulations.

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