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Reposition of galloyl derivative/ gallate equivalent class of molecule(s) as an anti-sars-cov-2 and respiratory medicine of covid-19

Author: 
Dipankar Bhattacharyya
Subject Area: 
Health Sciences
Abstract: 

As galloyl derivative/ gallate equivalent class of molecule(s) were found to have more or less bitter taste and as well as strong antioxidant, antiinflammatory, strong antiproliferative, antimutagenic, anticancer, antitumor, antiulcer, antiischemic, antiatherosclerotic, antidepressive/ antihypertensive, antidiabetic, antimalarial, antiarthritic, immunomodulatory, antiretroviral and anti-human coronavirus (anti-HCoV) like versatile properties as therapeutic as broad spectrum antiviral in the sense of host defensive manner, could be two in one role as it posing a CQ/HCQ like lot of similar functional bioactive- and similar physical bitterness properties or posing a similar structural property with multioxygenated and physically bitter compound like azithromycin (AZM)/ ivermectin (IVM) of anti-SARS-CoV-2 property and the galloyl/ gallate class as bearing similar polyhydroxy/ polyoxygenic type of molecule(s) could be therefore repurposed against novel coronavirus (nCoV) when compared with either bitter CQ/HCQ functionally or AZM/IVM structurally as special references, as well as it can act as a respiratory medicine/ natural ventilator of aerial oxygen by reopening the collapsed air ways of lung in COVID-19 symptomatic patients depending on their strong antioxidantal and antiinflammatory/ immunomodulatory properties so that normal breath/ sufficient aerial oxygen can enter easily when treated. Since the said class of molecule(s) as it possess the strong antiinflammatory property might be involved in decreasing proinflammatory cytokines and/ increasing antiinflammatory cytokines and as well as able to stop the episode of cytokine storm, a key step in ARDS, which was further strengthen by a preliminary study where gallate equivalent enriched Abroma augusta leaves hydroalcoholic extract (AALHAE) (50%) and AALHAEplus (50%) has been implemented on a few covid-19 suspected moderate and severe symptomatic patients respectively from my Institute, a promising result was thus obtained. I believe from my experience that the gallate eqv enriched AALHAE/ AALHAEplus may have tremendous role on controlling distress of lung which is used to be damage-targetted by SARS-CoV-2 in serious symptomatic cases.

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