Background: Osteoarthritis (OA) is one of the most common forms of arthritis. It gets worse as the disease progress and leads to chronic pain, stiffness as well as reduced mobility of joints. There are many attributable risk factors like gender, advancing age, obesity as well as mechanical factors. The pathology of the disease is characterized by cartilage destruction, inflammation of synovial membranes causing weak muscular strength. There are many specific and sensitive biomarkers for OA which may be helpful in the management of the disease. Objective: The objective of the study was to highlight the role of several biomarkers like Interleukin-1 Beta (IL-1β) and Alkaline Phosphatase (ALP) in post menopausal knee osteoarthritic female patients. Material & Methods: The present study was carried out in 200 female subjects of the age group of 45-70 years out of which 100 postmenopausal females without osteoarthritis and 100 were knee osteoarthritis diagnosed postmenopausal patients were selected. The blood samples were collected from department of Orthopedics of UPUMS, Saifai, Etawah, and then the serum levels of Interleukin 1 Beta and Alkaline Phosphatase was measured. Results: IL-1β was significantly increased (P<0.001) and ALP was also increased (P<0.05), in female patients with knee osteoarthritic as compare to the control group. Also, the correlation is made between IL-1β and ALP and a negative correlation (r<0.0791) obtained in osteoarthritic female patients. Conclusion: The result of our study shows that the biochemical parameters IL-1β play a more significant role than the Alkaline Phosphatase in the development of osteoarthritis disease in post menopausal knee osteoarthritic female patients.
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