Nurses need to be prepared to play multidisciplinary roles before and during the process of organ donation. Trained organ donation Nurse could benefit the consent rates for organ donation by educating and guiding the families. Trained nurses play an important role in organ donation and transplantation by discussing medical criteria for assessment of donor, the determination of brain death, approaching families for consent and co coordinating with the transplant team. Medical floor Nurses, ICU/Emergency Department (ED) Nurses, Transplantation Nurses, Procurement Nurses should be involved in establishment of a successful transplantation program.