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In-silico analysis of receptors involved in down regulation of beta 2 microglobulin (b2m): a potential drug target

Author:

Sanjana S., Uday, J. and Hariprasad, T. P. N.

Subject Area:

Life Sciences

Abstract:

Beta 2 microglobulin (B2M) is a small ~11KD protein. Increased level of Beta-2-microglobulin (B2M) leads to several diseases like amyloidosis, peripheral arterial disease, coronary heart disease, cancer and inflammatory diseases. B2M downstream signalling is mediated by activation of the protein kinase A/cyclic AMP (cAMP) mediated by potential interaction with Phosphatidylinositol 3-kinase and Mitogen-activated protein kinase signalling in humans. In this study an insilico approach was carried out to identify the possible receptors which interact with this protein and induce the downstream signalling which may be a further used to explore therapeutic target for treating cancer.

PDF file:

31133.pdf

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