CALL FOR PAPERS

Author Information

CERTIFICATE

IMPACT FACTOR 2021

Subject Area

Life Sciences / Biology
Architecture / Building Management
Asian Studies
Business & Management
Chemistry
Computer Science
Economics & Finance
Engineering / Acoustics
Environmental Science
Agricultural Sciences
Pharmaceutical Sciences
General Sciences
Materials Science
Mathematics
Medicine
Nanotechnology & Nanoscience
Nonlinear Science
Chaos & Dynamical Systems
Physics
Social Sciences & Humanities

Why Us? >>

Open Access
Peer Reviewed
Rapid Publication
Life time hosting
Free promotion service
Free indexing service
More citations
Search engine friendly

Plagiarism Detection

IJCR is following an instant policy on rejection those received papers with plagiarism rate of more than 20%. So, All of authors and contributors must check their papers before submission to making assurance of following our anti-plagiarism policies.

In silico modelling of engineered buforin ii

Author:

Golla Kamala, Vutukuru, S. S. and Chand Pasha

Subject Area:

Life Sciences

Abstract:

Protein engineering-based drug designing is quite interesting research area for invention of peptide based drugs. The current study is aimed to engineer BuforinII antimicrobial peptide by Mechanism based protein engineering. Template BuforinII was obtained from NCBI database and its similar sequences were retrieved by using Blast P. Protein engineering resulted in a total of 200 variable peptides. 3D model developed for 200 variable peptides and BuforinII by using PEPFOLD server. The developed models were evaluated by RAMPAGE and Q-Mean servers. Based on the Ramachandran Plot, Z-score value and SVM-score of DNA binding studies, the P11A/V12P variant was found to be highly stable and more DNA binding compared with wild and remaining variants. The developed variants can be used for antimicrobial studies in laboratory.

PDF file: