The capacity to replace missing parts of the body lost due to disease process, trauma or other reasons have been fascinating scientist since decades. Regeneration of lost part of skin intestinal and buccal epithelium, blood etc by the body paved the way for search of basic parent cell from which all other cells are derived. This led to the discovery of stem cells in1960 and since then stem cell-based treatments are being used and investigated in medicine for neural, cardiovascular and autoimmune diseases. In recent history, stem cells from teeth have been researched and is said to be able to cure various tooth-related and maxillofacial defects. This article presents a brief introduction on stem cell and its futuristic application in the field of dentistry.